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H. Shibata

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    P1.01 - Poster Session 1 - Cancer Biology (ID 143)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Biology
    • Presentations: 1
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      P1.01-006 - Intra-tumor pressure of lung cancer may correlate tumor aggressiveness (ID 1381)

      09:30 - 16:30  |  Author(s): H. Shibata

      • Abstract

      Intra-tumor pressure (ITP) was reported to be one of prognostic factors for head and neck cancer and hepatocellular carcinoma. It was reported that ITP of rectal cancer fell after Bevacizumab treatment. We measured ITP of lung cancer and investigated relationship between ITP and clinicopathological factors of lung cancer.

      After institutional review board approval, we measured ITP in the center of the tumor after resection of lung cancer using Ultra-Miniature Mikro-Tip Pressure Transducer Catheters (SPR1000, Millar). Lung cancer showing pure ground glass opacity (GGO) appearance in CT was excluded from this study. Between September 2009 and January 2013, 219 lung cancer patients, 142 male and 77 female, entered the study. Mean age of patients was 70 ± 10 year old (range: 39 to 87). The histologic types of lung cancer were adenocarcinoma (AD) in 148 patients, squamous cell carcinoma (SqCC) in 52 patients, adenosquamous carcinoma (AdSq) in 10 patients, and others. The clinical (c) T stages were T1a in 69 patients, T1b in 64 patients, T2a in 60 patients, T2b in 11 patients, T3 in 14 patients, and T4 in one patient. The cN stages were N0 in 187 patients, N1 in 22 patients, N2 in 8 patients, and N3 in 2 patients. The cStages were IA in 122 patients, IB-IIIB in 97 patients. The pathological (p) T stages were T1a in 84 patients, T1b in 45 patients, T2a in 67 patients, T2b in 9 patients, T3 in 9 patients, and T4 in 4 patients. The pN stages were N0 in 183 patients, N1 in 21 patients, N2 in 14 patients. The pStages were IA in 117 patients, IB in 53 patients, IIA in 19 patients, IIB in 6 patients, IIIA in 21 patients, and IIIB in 2 patients. Mean maximal diameter of the tumors on CT was 2.7±1.4cm (range: 0.8 to 7.9). Of these tumors, 59 showed part-solid and 147 showed solid appearance on CT.

      Mean ITP was 8.7 ± 6.5 mmHg(range: 0 to 37.2). Mean ITPs according to histological type were as follows: 8mmHg in AD, 10mmHg in SqCC, 7mmHg in AdSq. Mean maximal standardized uptake value (SUVmax) in fluoro-deoxy glucose-positron emission tomography was 4.6±3.5 (range: 0.3 to 15.1). ITP correlated to maximal diameter of tumor on CT (r=0.312) and pT factor (r=0.336). The ITP in pN0 (8mmHg) was significantly lower than that in pN(+) (12mmHg) (p=0.005). The ITP in pStage IA patients (6mmHg) was significantly lower than that in other stages patients (11mmHg) (p=0.001). The ITP of tumors showing solid appearance (10mmHg) was significantly higher than that of tumors showing part-solid (5mmHg). While ITP correlated to SUVmax (r=0.402), lymphatic vessel invasion (r=0.269), blood vessel invasion (r=0.293), pleural invasion (r=0.287), tumor grade (r=0.238), MIB-1 index (r=0.292), did not correlate to microvessel density (CD34) .

      ITP showed correlation to tumor aggressiveness factors of lung cancer.