Session Information
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WCLC 2018
19th World Conference on Lung Cancer
Conference Program for the 19th World Conference on Lung Cancer in Toronto, Canada
Download PDF of the Abstract Book: Click Here.
Presentation Date(s):- Sept 23 - 26, 2018
- Total Presentations: 2391
September 23 Sun
Sep 23 Monday
September 24 Mon
Sep 24 Tuesday
September 25 Tue
Sep 25 Wednesday
September 26 Wed
Sep 26
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PC01 - Controversies in Mesothelioma
- 10:30 - 12:00
- 9/24/2018
- Location: Room 205 AC
- Type: Pro-Con Session
- Track: Mesothelioma
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PC01.01 - PRO Intrapleural Chemotherapy Is It the Future?
10:30 - 10:45 | Presenter: Isabelle Opitz, Alessandra Curioni Fontecedro
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PC01.02 - CON Intrapleural Chemotherapy Is It the Future?
10:45 - 11:00 | Presenter: David Rice
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No abstract available for this presentation
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PC01.03 - PRO IO in Mesothelioma Should Only Be Given on Clinical Trials
11:00 - 11:15 | Presenter: Penelope Bradbury
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No abstract available for this presentation
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PC01.04 - CON in Mesothelioma Should Only Be Given on Clinical Trials
11:15 - 11:30 | Presenter: Evan Alley
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No abstract available for this presentation
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PC01.05 - PRO Radiation Options: Are We SMART Enough?
11:30 - 11:45 | Presenter: John Cho
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No abstract available for this presentation
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PC01.06 - CON Radiation Options: Are We SMART Enough?
11:45 - 12:00 | Presenter: Charles B. Simone
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No abstract available for this presentation
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ES01 - Advances in Lung Cancer Screening Through Imaging
- 13:30 - 15:00
- 9/24/2018
- Location: Room 206 F
- Type: Educational Session
- Track: Screening and Early Detection
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ES01.01 - Image Quality Characteristics and Nodule Growth Measurement, Medical Physics and Machine Parameters
13:30 - 13:50 | Presenter: Ricardo S Avila
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ES01.02 - Image Interpretation and Advances from the Perspective of the Radiologist
13:50 - 14:10 | Presenter: David F Yankelevitz
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No abstract available for this presentation
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ES01.03 - Deep Machine Learning for Screening LDCT
14:10 - 14:30 | Presenter: Bram Van Ginneken
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ES01.04 - Multi-Phasic Screening - Can We Address Competing Causes of Morbidity * Mortality Such as Coronary Artery Disease and COPD
14:30 - 14:50 | Presenter: Rozemarijn Vliegenthart
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ES01.05 - Q&A
14:50 - 15:00
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No abstract available for this presentation
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MA04 - Novel Approaches with IO
- 13:30 - 15:00
- 9/24/2018
- Location: Room 107
- Type: Mini Oral Abstract Session
- Track: Immunooncology
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MA04.01 - Cemiplimab, a Human Monoclonal Anti-PD-1, Alone or in Combination with Radiotherapy: Phase 1 NSCLC Expansion Cohorts
13:30 - 13:35 | Presenter: Victor Moreno | Author(s): Marta Gil-Martin, Melissa L. Johnson, Raid Aljumaily, Maria Pilar Lopez-Criado, Donald W Northfelt, Marka Crittenden, Salma Jabbour, Lee Rosen, Emiliano Calvo, Kyriakos P Papadopoulos, Pilar Garrido, Asuncion Hervás Morón, Petra Rietschel, Kosalai Mohan, Jingjin Li, Elizabeth Stankevich, Minjie Feng, Israel Lowy, Matthew Fury
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MA04.02 - Responses and Durability in NSCLC Treated With Pegilodecakin and Anti-PD-1
13:35 - 13:40 | Presenter: Edward B Garon | Author(s): Deborah J. Wong, Jeffrey G. Schneider, Raid Aljumaily, W. Michael Korn, Jeffrey R. Infante, Manish Patel, Karen A. Autio, Kyriakos P Papadopoulos, Aung Naing, Nashat Y. Gabrail, Pamela N. Munster, Jonathan W. Goldman, Annie Hung, Peter Van Vlasselaer, Joseph Leveque, Martin Oft, David R. Spigel
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MA04.03 - Immunotherapy for Non-Small Cell Lung Cancers (NSCLC) with Oncogenic Driver Mutations: New Results from the Global IMMUNOTARGET Registry
13:40 - 13:45 | Presenter: Oliver Gautschi | Author(s): Alexander Drilon, Julie Milia, Amelie Lusque, Laurent Mhanna, Bob T. Li, Joshua K Sabari, Alexis B Cortot, Benjamin Besse, Laura Mezquita, Ben J Solomon, Alesha A Thai, Sebastien Couraud, Remi Veillon, Céline Mascaux, Fabrice Barlesi, Michael Van Den Heuvel, Robert D Schouten, Heather A Wakelee, Angela Mah, Ross Camidge, Terry L. Ng, Nir Peled, Yosef Lilach, Sanjay Popat, Sai-Hong Ignatius Ou, Viola Zhu, Vamsidhar Velcheti, Alessandra Curioni Fontecedro, Dilara Akhoundova, Martin Früh, Gerard Zalcman, Valerie Gounant, Silvia Novello, Paolo Bironzo, Enriqueta Felip, Alex Martinez-Marti, Denis Moro-Sibilot, Rafael Rosell, Niki Karachaliou, Martin Schuler, Martin Wiesweg, Joachim Diebold, Julien Mazieres
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MA04.04 - Discussant - MA 04.01, MA 04.02, MA 04.03
13:45 - 14:00 | Presenter: Jose Pacheco
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MA04.05 - Outcomes in NSCLC Patients Treated with First-Line Pembrolizumab and a PD-L1 TPS of 50-74% vs 75-100% or 50-89% vs 90-100%
14:00 - 14:05 | Presenter: Mark M. Awad | Author(s): Elizabeth Jimenez Alguilar, Justin F Gainor, Sasha Kravets, Sara Khosrowjerdi, Christine A Lydon, Anika Adeni, Safiya Subegdjo, Hira Rizvi, Matthew D. Hellmann
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MA04.06 - PD-1 Blockade Promotes Hyperprogressive Disease in NSCLC Through Macrophages Activation via Antibody-Fc/FcR Interaction
14:05 - 14:10 | Presenter: Gabriella Sozzi | Author(s): Michele Sommariva, Massimo Moro, Claudia Proto, Diego Signorelli, Monica Ganzinelli, Sabina Sangaletti, Mattia Boeri, Giuseppe Lo Russo, Simona Ferro, Elena Tassi, Veronica Huber, Lucia Sfondrini, Massimo Milione, Claudio Tripodo, Mario Colombo, Andrea Anichini, Andrea Balsari, Licia Rivoltini, Marina Chiara Garassino
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MA04.07 - MicroRNA-Based Liquid Biopsy Combines with PD-L1 Tumor Expression to Predict Response to Immunotherapy in Advance NSCLC Patients
14:10 - 14:15 | Presenter: Mattia Boeri | Author(s): Massimo Milione, Diego Signorelli, Claudia Proto, Giuseppe Lo Russo, Carlotta Galeone, Giovanni Centonze, Ugo Pastorino, Marina Chiara Garassino, Gabriella Sozzi
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MA04.08 - Discussant - MA 04.05, MA 04.06, MA 04.07
14:15 - 14:30 | Presenter: Patrick M Forde
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MA04.09 - Neoadjuvant Atezolizumab in Resectable Non-Small Cell Lung Cancer (NSCLC): Updated Results from a Multicenter Study (LCMC3)
14:30 - 14:35 | Presenter: Valerie W Rusch | Author(s): Jamie E Chaft, Bruce E Johnson, Ignacio I. Wistuba, Mark G Kris, Jay M Lee, Paul A. Bunn, Jr., David J Kwiatkowski, Karen L. Reckamp, David J. Finley, Eric B. Haura, Saiama N. Waqar, Robert C. Doebele, Edward B Garon, Justin Blasberg, Alan Nicholas, Katja Schulze, See Phan, Mayank Gandhi, David P Carbone
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MA04.10 - Comprehensive Peripheral Blood Immunophenotyping and T-Cell Clonal Analysis During Neoadjuvant Immunotherapy with Atezolizumab in NSCLC
14:35 - 14:40 | Presenter: Filiz Oezkan | Author(s): Kai He, Dwight Hall Owen, Maciej Pietrzak, Rhonda Kitzler, Rebecca Pearson, Alan Nicholas, Paul A. Bunn, Jr., Mark G Kris, David J. Kwiatkowski, Bruce E Johnson, Fred R. Hirsch, Ignacio I. Wistuba, Valerie W Rusch, Jay M. Lee, Mayank Gandhi, Katja Schulze, David S. Shames, Gerard Lozanski, David P Carbone
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MA04.11 - Neoantigen Targeting and T Cell Reshaping in Resectable NSCLC Patients Treated with Neoadjuvant PD-1 Blockade
14:40 - 14:45 | Presenter: Kellie Nicole Smith | Author(s): Margueritta El Asmar, Jiajia Zhang, Justina X Caushi, Zhicheng Ji, Valsamo Anagnostou, Tricia R Cottrell, Hok Yee Chan, Prerna Suri, Haidan Guo, Kristen A. Marrone, Jarushka Naidoo, Taha Merghoub, Jamie E Chaft, Matthew D. Hellmann, Janis M Taube, Julie R. Brahmer, Patrick M Forde, Victor Velculescu, Drew M Pardoll, Hongkai Ji
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MA04.12 - Discussant - MA 04.09, MA 04.10, MA 04.11
14:45 - 15:00 | Presenter: Alex Adjei
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No abstract available for this presentation
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MA05 - Improving Outcomes in Locoregional NSCLC II
- 13:30 - 15:00
- 9/24/2018
- Location: Room 105
- Type: Mini Oral Abstract Session
- Track: Treatment of Locoregional Disease - NSCLC
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MA05.01 - E6508: Phase II Study of Immunotherapy with Tecemotide and Bevacizumab after Chemoradiation in Unresectable Stage III NS-NSCLC
13:30 - 13:35 | Presenter: Jyoti Patel | Author(s): Ju-Whei Lee, Henry Wagner Jr, David P Carbone, Anil Shanker, Leora Horn, Melissa L. Johnson, David E Gerber, Jane Jijun Liu, Millie S Das, Mohammad Ali Al-Nsour, Christopher S R Dakhil, Suresh S. Ramalingam, Joan Schiller
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MA05.02 - PACIFIC Subgroup Analysis: Pneumonitis in Stage III, Unresectable NSCLC Patients Treated with Durvalumab vs. Placebo After CRT
13:35 - 13:40 | Presenter: Johan F. Vansteenkiste | Author(s): Jarushka Naidoo, Corinne Faivre-Finn, Mustafa Özgüroğlu, Augusto Villegas, Davey Daniel, Shuji Murakami, Rina Hui, Ki Hyeong Lee, Byoung Chul Cho, Kaoru Kubota, Lynne Poole, Catherine Wadsworth, Phillip A. Dennis, Scott J Antonia
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MA05.03 - Immune Microenvironment and its Association with Adjuvant Chemotherapy Benefit in Locoregionally Advanced Lung Adenocarcinoma
13:40 - 13:45 | Presenter: Raj Ghanshyam Vaghjiani | Author(s): Takashi Eguchi, Navin Chintala, Xiaoyu Li, Rania G Aly, Katsura Emoto, Kay See Tan, David R. Jones, Prasad S. Adusumilli
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MA05.04 - Discussant - MA 05.01, MA 05.02, MA 05.03
13:45 - 14:00 | Presenter: Scott N. Gettinger
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MA05.05 - Photon-Based Cardiac Sparing Via Volumetric Modulated Arc Therapy in Thoracic Radiation Therapy for Locally Advanced Non-Small Cell Lung Cancer
14:00 - 14:05 | Presenter: Matthew J Ferris | Author(s): Katherine Sykes, Oluwatosin A Kayode, Jonathan Wolf, Robert H Press, Jeffrey M Switchenko, Walter John Curran, Jr., Kristin A Higgins
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MA05.06 - Locally Advanced Lung Cancer Radiotherapy in Deep Inspiration Breath Hold: Dosimetric Benefits from a Prospective Trial
14:05 - 14:10 | Presenter: Mirjana Josipovic | Author(s): Marianne C Aznar, Jonas Scherman Rydhög, Jakob Borup Thomsen, Sidsel Marie Skov Damkjaer, Lotte Nygård, Mette Pøhl, Seppo W Langer, Lena Specht, Gitte Fredberg Persson
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MA05.07 - Dose Escalated Chemo-RT to 84 Gy in Stage III NSCLC Appears Excessively Toxic: Results from a Randomized Phase II Trial
14:10 - 14:15 | Presenter: Jan Nyman | Author(s): Stefan Bergström, Hedvig Björkestrand, Anna-Maja Svärd, Simon Ekman, Erik Lundin, Erik Holmberg, Mikael Johansson, Signe Friesland, Andreas Hallqvist
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MA05.08 - Discussant - MA 05.05, MA 05.06, MA 05.07
14:15 - 14:30 | Presenter: Benjamin H Lok
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MA05.09 - PFS and Cardiac-Toxicity-Adjusted-PFS As Predictors of OS in Locally Advanced NSCLC Treated with Concurrent Chemoradiation
14:30 - 14:35 | Presenter: Chen Hu | Author(s): Mitchell Machtay, James Dignam, Rebecca Paulus, Jeffrey Bradley
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MA05.10 - The Pathologic Response of Locally Advanced NSCLC Treated with Concomitant Chemoradiation to 60 Gy in Image Guided Radiation Therapy (IGRT)
14:35 - 14:40 | Presenter: Sarit Appel | Author(s): Jair Bar, Damien Urban, Amir Onn, Marina Perelman, Yaacov Richard Lawrence, Alon Ben-Nun, Ory Haisraely, Zvi Symon, Tatiana Rabin El Ezra, Edith Marom, Sivan Liberman, Efrat Ofek
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MA05.12 - Discussant - MA 05.09, MA 05.10, MA 05.11
14:45 - 15:00 | Presenter: Matthew Hatton
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No abstract available for this presentation
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MA06 - PDL1, TMB and DNA Repair
- 13:30 - 15:00
- 9/24/2018
- Location: Room 206 AC
- Type: Mini Oral Abstract Session
- Track: Biology
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MA06.01 - The Intrinsic PD-L1 Promotes Cellular Invasiveness Via their PD-1 Receptor in Lung Adenocarcinoma Cells
13:30 - 13:35 | Presenter: Wen-Pin Su | Author(s): Hung-Chang Wu, Shuen-Ru Yang, Jheng-Cheng Huang, Jing-Jou Yan, Wan-Chen Kao, Li-Chan Chang, Wu-Chou Su
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MA06.02 - Prospective Immunogenomic Profiling of Non-Small Cell Lung Cancer: Genomic and Immune Profiling Updates from Project ICON
13:35 - 13:40 | Presenter: Marcelo Vailati Negrao | Author(s): Alexandre Reuben, Runzhe Chen, Boris Sepesi, Tatiana Karpinets, Edwin Roger Parra, Lorenzo Federico, Luis M Vence, Annikka Weissferdt, Hai T Tran, Ara A Vaporciyan, Cara Haymaker, Marie-Andrée Forget, Mayra E Vasquez, Eric A Prado, Chi-Wan Chow, Jianhua Zhang, Junya Fujimoto, Jack A Jack A. Roth, Ismail M Meraz, Emily Roarty, Lara Lacerda Landry, Heidi E Wagner, Elena Bogatenkova, Chantale Bernatchez, P. Andrew Futreal, Ignacio I. Wistuba, Stephen Swisher, John V Heymach, Don Lynn Gibbons, Jianjun Zhang
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MA06.03 - PD-1 and Id-1 Combined Blockade Impacts Tumor Growth and Survival Through PD-L1 Expression and Tumor Infiltration by Immune-Related Cells
13:40 - 13:45 | Presenter: Ignacio Gil-Bazo | Author(s): Iosune Baraibar, Marta Roman Moreno, Ines Lopez, Jesus Corral, Juan Jose Lasarte, Alfonso Calvo, Silve Vicent, Daniel Ajona
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MA06.04 - Discussant - MA 06.01, MA 06.02, MA 06.03
13:45 - 14:00 | Presenter: Akihiko Yoshida
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MA06.05 - The Micro-Environmental Cross Talk Between Mast Cells and Lung Cancer Cells Through Cell-to-Cell Contact
14:00 - 14:05 | Presenter: Rachel Shemesh | Author(s): Yaara Gorzalczany, Smadar Geva, Laila C. Roisman, Ronit Sagi-Eisenberg, Nir Peled
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MA06.06 - An Ex-Vivo Patient-Derived, Immunocompetent (PDI) Culture System to Evaluate Immunotherapeutic Agents’ Anti-Tumor Efficacy
14:05 - 14:10 | Presenter: Zachary E. Tano | Author(s): Stefan Kiesgen, Navin Chintala, Jordan Dozier, John Messinger, Kay See Tan, Prasad S. Adusumilli
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MA06.07 - Genetic and Epigenetic Alterations are Associated with Tumor Mutation Burden in Non-Small Cell Lung Cancer
14:10 - 14:15 | Presenter: Liang-Liang Cai | Author(s): Hua Bai, Zhi-Jie Wang, Shuhang Wang, Jian-Chun Duan, Shu-Geng Gao, Jie He, Jie Wang
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MA06.08 - Discussant - MA 06.05, MA 06.06, MA 06.07
14:15 - 14:30 | Presenter: Jyoti Patel
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MA06.09 - XRCC6BP1: A DNA Repair Gene in Cisplatin Resistant Lung Cancer Stem Cells That May Predict Survival Outcomes in Patients
14:30 - 14:35 | Presenter: Martin P Barr | Author(s): Robert Farrell, Saravjeet Singh, Emma Foley, Yuexi He, Lauren Brady, Vincent Young, Ronan Ryan, Siobhan Nicholson, Niamh Leonard, Sinead Cuffe, Stephen Finn
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MA06.10 - Germline Mutation in ATM Affect Lung Cancer Risk with High Effect
14:35 - 14:40 | Presenter: Xuemei Ji | Author(s): Dakai Zhu, Claudio Pikielny, Olga Gorlova, Maria Teresa Landi, John Kirkpatrick Field, Paul Brennan, Mattias Johansson, Rayjean J. Hung, James D McKay, Christopher Ian Amos
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MA06.11 - Distinct Origins of Lymphatic and Brain Metastasis in Lung Cancer
14:40 - 14:45 | Presenter: Tao Jiang | Author(s): Yan Yan, Caicun Zhou
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MA06.12 - Discussant - MA 06.09, MA 06.10, MA 06.11
14:45 - 15:00 | Presenter: Rebecca Heist
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MA07 - Towards Survivorship: The Landscape, Supports and Barriers
- 13:30 - 15:00
- 9/24/2018
- Location: Room 205 AC
- Type: Mini Oral Abstract Session
- Track: Advocacy
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MA07.01 - No Longer Outliers: Understanding the Needs of Long-Term Lung Cancer Survivors
13:30 - 13:35 | Presenter: Maureen Rigney | Author(s): Jennifer C King, Andrew Ciupek
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MA07.02 - Line of Therapy and Patient Preferences Treating Lung Cancer: A Discrete-Choice Experiment
13:35 - 13:40 | Presenter: Andrea Ferris | Author(s): John F.P. Bridges, Upal Basu Roy, Ellen Janssen
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MA07.03 - Attitudes to Lung Cancer in Europe: Findings from a Global Consumer Survey
13:40 - 13:45 | Presenter: Jesme Fox | Author(s): Aoife McNamara, Maureen Rigney, Greg Manuel, Sarah Winstone
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MA07.04 - Discussant - MA 07.01, MA 07.02, MA 07.03
13:45 - 14:00 | Presenter: Kim Norris
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MA07.05 - Psychosocial Needs and Programs of Cancer Patients/Survivors and Their Relatives: Unmet Needs from an International Study
14:00 - 14:05 | Presenter: Csaba László Dégi | Author(s): Samantha Serpentini, Savita Goswami
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MA07.06 - Telephonic Communication In Palliative Care For Better Management Of Terminal Cancer Patients In Rural India - An NGO Based Approach.
14:05 - 14:10 | Presenter: Nabanita Mandal
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MA07.07 - Identifying the Severity of Psychosocial Symptoms Among Patients Diagnosed with Lung Cancer. Do We Really Need Emotional Support Groups?
14:10 - 14:15 | Presenter: Arooj Fatima | Author(s): Syed Sammar Abbas Zaidi
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MA07.08 - Discussant - MA 07.05, MA 07.06, MA 07.07
14:15 - 14:30 | Presenter: Jennifer C King
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MA07.09 - Willingness to Perform Multiple Biopsies to Improve Quality of Lung Cancer Care: Understanding the Oncologists’ Perspective
14:30 - 14:35 | Presenter: Upal Basu Roy | Author(s): Margery Jacobson, Andrea Ferris
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MA07.10 - Utilizing a Personalized Navigation Program to Identify Barriers and Increase Clinical Trial Participation Among Lung Cancer Patients
14:35 - 14:40 | Presenter: Andrew Ciupek | Author(s): Tara Perloff, Achintya Jaitly, Jennifer C King
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MA07.11 - Drug Price Comparison in Advanced Lung Cancer – High Cost Prices is Accompanied by Patient Benefits?
14:40 - 14:45 | Presenter: Luciene Bonan
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MA07.12 - Discussant - MA 07.09, MA 07.10, MA 07.11
14:45 - 15:00 | Presenter: Govind Babu Kanakasetty
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MS05 - Diagnostic Dilemma in Lung Cancer
- 13:30 - 15:00
- 9/24/2018
- Location: Room 201 BD
- Type: Mini Symposium
- Track: Pathology
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MS05.01 - Staging and Pathology of Multiple Lung Nodules
13:30 - 13:50 | Presenter: Alain C. Borczuk
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MS05.02 - Defining Invasion in Minimally Invasive Adenocarcinoma
13:50 - 14:10 | Presenter: Masayuki Noguchi
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MS05.03 - Tumor Heterogeneity in Lung Cancer
14:10 - 14:30 | Presenter: Elisabeth Brambilla
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MS05.04 - Diagnosis and Classification in Biopsies
14:30 - 14:50 | Presenter: Andre Moreira
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MS05.05 - Q&A
14:50 - 15:00
- Abstract
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MS06 - Practical Issues in the Management of Oligometastatic NSCLC
- 13:30 - 15:00
- 9/24/2018
- Location: Room 206 BD
- Type: Mini Symposium
- Track: Oligometastatic NSCLC
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MS06.01 - The Role of Radiation in Treating the Mets
13:30 - 13:45 | Presenter: Hak Choy
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MS06.02 - The Role of Interventional Pulmonology and Radiology
13:45 - 14:00 | Presenter: Kwun M Fong
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MS06.03 - The Role of Surgical Resection
14:00 - 14:15 | Presenter: Boris Sepesi
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MS06.04 - Systemic Therapy for Oligomets: Before, During, or After Local Therapies?
14:15 - 14:30 | Presenter: Ross Camidge
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MS06.05 - The Special Case of Brain Metastases: Systemic Therapy, Radiation or Both?
14:30 - 14:45 | Presenter: Laurie Gaspar
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MS06.06 - Q&A
14:45 - 15:00
- Abstract
No abstract available for this presentation
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MS07 - Antibody-Drug Conjugates in Advanced NSCLC
- 13:30 - 15:00
- 9/24/2018
- Location: Room 205 BD
- Type: Mini Symposium
- Track: Advanced NSCLC
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MS07.01 - Basic Science
13:30 - 13:50 | Presenter: David E Gerber
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MS07.02 - Pharmacology
13:50 - 14:10 | Presenter: Christian Rolfo
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MS07.03 - Clinical Data
14:10 - 14:30 | Presenter: Thomas E. Stinchcombe
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MS07.04 - Future Directions
14:30 - 14:50 | Presenter: Silvia Novello | Author(s): Annapaola Mariniello
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MS07.05 - Q&A
14:50 - 15:00
- Abstract
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MS08 - Lung Cancer in the Real World
- 13:30 - 15:00
- 9/24/2018
- Location: Room 201 F
- Type: Mini Symposium
- Track: Treatment in the Real World - Support, Survivorship, Systems Research
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MS08.01 - How Can Real World Data Improve Clinical Evidence Generation and Impact Regulatory Bodies - European Perspective
13:30 - 13:45 | Presenter: Yolande Lievens
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MS08.02 - How Can Real World Data Improve Clinical Evidence Generation and Impact Regulatory Bodies – US Perspective
13:45 - 14:00 | Presenter: Gideon Blumenthal
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MS08.03 - Sources of Real World Data: Research Designs, Statistical Modelling and Quality Assurance Requirements
14:00 - 14:15 | Presenter: Mary W. Redman
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MS08.04 - The ASCO Perspective
14:15 - 14:30 | Presenter: Bruce E Johnson
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MS08.05 - The ESTRO Perspective
14:30 - 14:45 | Presenter: Umberto Ricardi
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MS08.06 - Discussion
14:45 - 15:00
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