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J. Kang
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Poster Session (ID 8)
- Event: ACLC 2018
- Type: Poster Session
- Track:
- Presentations: 1
- Moderators:
- Coordinates: 11/07/2018, 00:00 - 00:00, Poster Hall
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P087 - TNM Staging Inversely Correlates with Age in ALK-positive Lung Cancer (ID 63)
00:00 - 00:00 | Author(s): J. Kang
- Abstract
Background:
The patients with lung cancer and anaplastic lymphoma kinase (ALK) rearrangement predominantly occur younger. However, few large-scale studies revealed the clear correlation between age, tumor nodes metastases (TNM) staging and morbidity in this rare population.
Method:
The age of ALK-positive lung cancer at initial diagnosis were compared between various TNM stages. Clinical characteristics, morbidity and prognosis were analyzed stratified by different age groups.
Results:
Of 411 patients, the younger group showed more frequent T3/4 stage (P = 0.014), more frequent lymph nodes metastasis (P = 0.011) and more frequent distant metastasis (P = 0.015). Across the entire patient cohort, the median age was 51 years, which decreased steadily with clinical stages (stage I/II vs. III vs. IV, 55 vs. 52 vs. 49 years). There was significant inverse correlation between age and clinical stages (P < 0.001). These laws also existed at various T, N, M categories. What was more, morbidity of ALK rearrangement manifested a steady downward trend with older age groups (?40 vs. 40-49 vs. 50-59 vs. ?60 years: 18.8% vs. 11.6% vs. 5.0% vs. 2.2%). Surprisingly, ALK-positive patients with stage IIIb-IV disease had much higher incidence than the patients with stage I-IIIa disease (6.1% vs. 3.4%, P < 0.001). Finally, the ALK-positive patients aged younger showed poorer outcomes compared with the older group.
Conclusion:
TNM staging exhibited a significant inverse correlation with age in ALK-positive lung cancer. More unique therapeutic and research strategies should be required in these patients of young age.