Author of

• 16549

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  P1.02 - Poster Session with Presenters Present (ID 454)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Biology/Pathology
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16591

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    P1.02-042 - Detection of ALK Protein Expression in Lung Adenocarcinomas, a Consecutive Series of Cases from Northeastern Brazil (ID 5741)

    14:30 - 15:45  |  Author(s): I.S. Costa
    • Abstract

    Background:
    There have been very few studies on ALK status in lung adenocarcinomas in Latin American population. No prior reports in Northeastern Brazil have been published.
    
    Methods:
    We analyzed ALK protein expression with a specific antibody (D5F3 clone) with the Ventana system in a series of consecutive cases from Northeastern Brazil, a previously untested population, and correlated with histologic subtypes according to the 2015 WHO Classification.
    
    Results:
    A total of 94 patients (55% female, mean age 62 years) were tested, including 51 solid, 29 acinar, 6 lepidic, 6 papillary predominant and 2 sarcomatoid carcinomas with adenocarcinoma components. There were 9 positive cases (9.5%), 5 solid predominant, 3 acinar predominant and 1 lepidic. One of the 3 acinar cases had a mucinous component. The positive cases were more often male (p<0.05) with no significant differences in relation to age, smoking history or histologic subtype. The negative cases showed a 32% EGFR mutation rate. Follow-up will be presented.
    
    Conclusion:
    We will describe a series of consecutive adenocarciomas from a population with unknown ALK status with a higher than expected rates, and correlate with the 2015 WHO Classification of Tumors.