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X. Zhai
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P2.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 210)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.02-035 - Is There an Optimal Time to Initiate Adjuvant Chemotherapy in Order to Predict the Benefit of Survival in Non-Small Cell Lung Cancer? (ID 2341)
09:30 - 17:00 | Author(s): X. Zhai
- Abstract
Background:
Adjuvant chemotherapy (ACT) improves the survival for completely resected non-small cell lung cancer (NSCLC) patients. However, there are very few reports to explore the correlation between time of initiation of adjuvant chemotherapy (TTAC) and survival.
Methods:
208 completely resected NSCLC patients received adjuvant chemotherapy in Cancer Hospital, Chinese Academy of Medical Sciences from 2001-2010 were analyzed. TTAC was measured from the date of surgery to initiation of ACT. Disease-free survival (DFS) was defined as the duration from the surgery to the time of relapse or last follow-up. Optimal cutoff value of the TTAC was determined by maximally selected log-rank statistics. Survival analysis was performed using Kaplan–Meier estimates, log-rank tests and Cox’s proportional hazards regression analysis. Propensity score matching (PSM) was used, and a survival analysis of the match data was carried out.
Results:
The best discriminating cutoff value of TTAC was the 50th day(Figure 2). According to the cutoff value of 50, patients were divided into 2 groups, group1 (≤50days, n=183) and group2 (>50 days, n=25). Figure 1 shows the baseline characteristics of the two groups of patients before and after PSM .There was significant difference in DFS between the two groups (mDFS: 737days vs. 369days, P=0.005)(Figure 2), and the TTAC was found to be a significant predictive factor for DFS in multivariable analysis (P =0.035).Unfortunately, DFS was not continually significant difference in 22 PSM pairs (mDFS:576days vs. 369days,P=0.122) (Figure 2).Figure 1Figure 2
Conclusion:
TTAC does not appear to be associated with DFS in NSCLC. The conclusion was limited by the small sample size; therefore the number of patients between the groups was not close. Larger sample of cases should be warranted in future.
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P3.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 211)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.02-032 - Effect of Age on Adjuvant Chemotherapy after Resection of Non-Small Cell Lung Cancer (ID 2343)
09:30 - 17:00 | Author(s): X. Zhai
- Abstract
Background:
Adjuvant chemotherapy (ACT) improves the survival for completely resected non-small cell lung cancer (NSCLC) patients. However, there are few reports to explore the effect of age on the efficacy of adjuvant chemotherapy of NSCLC after surgery.
Methods:
Patients received adjuvant chemotherapy after surgery in Cancer Hospital, Chinese Academy of Medical Sciences from 2001-2010 were analyzed. Disease Free Survival (DFS) of the two groups of patients was compared in terms of their age. Survival analysis was performed using Kaplan–Meier estimates, log-rank tests and Cox’s proportional hazards regression analysis. Propensity score matching (PSM) was used, and a survival analysis of the match data was carried out.
Results:
The data of 256 patients with stage I to stage Ⅲ NSCLC who underwent completely resection was analyzed. Those two groups,patients aged≤65 years (27~65, n=206) and patients aged＞65 years (66~72, n=50) ,were compared. Figure 1 shows the baseline characteristics of the two groups of patients before and after PSM. There was no significant difference in DFS between the two groups (mDFS: 594 days vs. 554 days, P=0.951) (Figure 2), and the age was not associated with DFS in multivariable analysis (P =0.602). DFS was continually not significant difference in 40 PSM pairs (mDFS: 600 days vs. 554 days, P=0.731) (Figure 2).Figure 1Figure 2
Conclusion:
The results suggest that older patients do not appear a shorter DFS than younger. Thus, elderly patients should not be denied adjuvant chemotherapy based merely on age. The conclusion was limited by the small sample size; moreover, the number of patients between the groups was not close. Larger sample of cases should be warranted in future.
