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N. Khanal
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P2.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 210)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.02-029 - Pre-Operative Pulmonary Function Tests (PFT) and Outcomes from Stage I and II Non-Small Cell Lung Cancer (NSCLC) Treated with Surgery (ID 2385)
09:30 - 17:00 | Author(s): N. Khanal
- Abstract
Background:
Pre-operative PFTs predict operative morbidity and mortality after resection in lung cancer. However, the impact of pre-operative PFT on overall survival (OS) in surgically resected stage I and II NSCLC is relatively less studied.
Methods:
This is a retrospective study of 149 patients who underwent surgical resection as first-line treatment for stage I and II NSCLC at a single center between 2003 and 2014. PFTs (FEV1, DLCO, both absolute values and percentage of predicted values were categorized into quartiles The Kaplan-Meier method and Cox regression analysis were used to determine whether PFTs predicted for OS. The t-test was used to compare the risk of post-op complications and length of stay greater than 10 days based on the results of PFTs and multivariate logistic regression was used for predictive modeling. P-value<0.05 was considered statistically significant.
Results:
The median age of the cohort was 68 years. The cohort was predominantly male (98.6%), current or ex-smokers (98%), with stage I NSCLC (82.76%). The majority of patients underwent a lobectomy (n=121, 81.21%). The predominant tumor histology was adenocarcinoma (n=70, 47%) followed by squamous cell carcinoma (n=61, 41%). The median follow-up of surviving patients was 53.2 months. Although DLCO was found to be a significant predictor of OS (HR: 0.93, 95% CI, 0.87-0.99; p=0.03), this was no longer significant on multivariate analysis. While PFTs did not predict for post-operative complications, worse PFTS were significant predictors of length of stay >10 days. Table 1. PFTs and Outcome:
OS=Overall Survival, LOS= Length of stay, ULN= Upper Limit of Normal *PFT as continuous variablesMultivariate model for of LOS > 10 days Odds Ratio(95% CI, p-value) FEV1 0.34(0.16-0.76,p=0.0087) FEV1 (percentage predicted) 0.96(0.94-0.99,p=0.0033) DLCO 0.78(0.68-0.90,p=0.0004) DLCO (percentage predicted) 0.96(0.94-0.99,p=0.0060)
Conclusion:
Preoperative PFTs did not predict for survival from resected early stage NSCLC, but did predict for longer hospital stays following surgery.
