Virtual Library
Start Your Search
V. Markovic
Author of
-
+
P2.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 210)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
-
+
P2.02-019 - Role of Sentinel Node Biopsy in Stage IA NSCLC Surgery (ID 151)
09:30 - 17:00 | Author(s): V. Markovic
- Abstract
Background:
Systematic mediastinal lymphadenectomy is still essential for an adequate intraoperative staging and adjuvant therapy of NSCLC. We tried to investigate still controversial role of sentinel node biopsy (SNB) in early stage non small cell lung cancer (NSCLC) surgery.
Methods:
A total of 72 patients with clinical T1N0MO NSCLC underwent SN navigation lobectomy using Tc-99 labeled tin colloid followed by systematic mediastinal lymphadenectomy (SML) in three years time period (2010-2013). Mapping of the mediastinal lymph nodes by their number and station followed by hystopathological evaluation was performed. Patients data were statistically analyzed.
Results:
Intraoperative SN was identified in 62 (87%) of these patients with 92% of accuracy. We found lobe specific skip nodal metastases in 7 (10%) patients resulting in upstaging. The incidence of ML metastases seemed to be more often in adenocarcinoma patients (p<0.05), but skip nodal metastases showed higher rate in squamous cell carcinoma patients. Intraoperative frozen section was not confirmed accurate for detecting micrometastases in two (4%) patients. Operative time was prolonged for 10 (8-25) minutes showing no difference in complication rate.
Conclusion:
Procedure showed absolute safety and high accuracy. Our results indicated that SN identification could replace mediastinal lymph node dissection in early stage NSCLC. Further clinical studies should be carried out in order to prove that minimally invasive mediastinal surgical procedures could be curative for T1N0MO NSCLC.
