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Y. Chen
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P1.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 224)
- Event: WCLC 2015
- Type: Poster
- Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.08-039 - Adjuvant Treatment of Thymic Carcinoma (ID 1139)
09:30 - 17:00 | Author(s): Y. Chen
- Abstract
Background:
Thymic carcinomas are rare tumors. Surgical resection is first considered. However, data for adjuvant treatment after surgery is limited
Methods:
We retrospectively reviewed records of our thymic carcinoma patients who were treated between 2004 and 2014. Data on age, smoking or not, performance status of each patient, TNM staging, surgical margin, type of adjuvant therapy, and type of chemotherapy were collected.
Results:
Thirty-two patients received surgical resection and 49 patients did not. Both PFS and OS were significantly longer among patients who received surgical resection (26.0 months vs 7.2 months, p<0.001; 37.8 months vs 14.8 months, p<0.001). Patients with stage III thymic carcinoma had a longer overall survival when they received surgical resection. (70.1 months vs 23.9 months, p=0.017). Among stage IV patients, those received extended thymothymectomy had a longer PFS than did not received surgery (10.6 months vs 7.0 months, p=0.003). Among all 32 patients (stage I-IV) who received surgery, twenty-one patients were R0 resection, 6 patients were R1 resection, and 5 patients were R2 resection. Among 21 patients who were R0 resection, 10 received adjuvant radiotherapy and had better PFS than those received adjuvant chemotherapy (n=2) or concurrent chemo-radiotherapy after surgery (n=4) (50.3 months vs 5.9 months vs 7.5 months, p=0.001).
Conclusion:
Surgical resection should always be considered first whenever possible in thymic carcinoma patients. Adjuvant radiotherapy had better PFS after R0 resection.
