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J.D. Lara
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P1.07 - Poster Session/ Small Cell Lung Cancer (ID 221)
- Event: WCLC 2015
- Type: Poster
- Track: Small Cell Lung Cancer
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.07-014 - Predictors of Survival in Small Cell Lung Cancer (SCLC) Patients (pts) < 50 Years of Age: Results from the California Cancer Registry (CCR) (ID 2416)
09:30 - 17:00 | Author(s): J.D. Lara
- Abstract
Background:
SCLC is an often lethal disease that commonly occurs in older individuals with a history of heavy tobacco use. Limited epidemiologic and outcomes data are available for young SCLC pts (< 50 years of age). We analyzed the CCR to explore the clinical variables related to cause specific survival (CSS) of young pts.
Methods:
SCLC pts diagnosed between 1998-2012 were included. Primary outcome was CSS. Hazard ratios (HR) for CSS were calculated using Cox Proportional Hazards (PH) models for all ages & for pts <50 years, adjusted for baseline variables: age, gender, stage, race, year of diagnosis, treatment, socioeconomic status (SES), and location (urban vs. rural).
Results:
We identified 22,863 SCLC pts, of which 975 were <50 years of age (4.2%). Demographics for pts <50 years: Males-51%; White-71%; Stage IV-60%; Chemotherapy-79%; Urban location-92%; high SES-28%. Fewer pts < 50 years were diagnosed in later years: from 40% in ‘98-’02 to 24% in ‘08-‘12. Results of multivariate Cox PH models are shown. (HR=Hazard Ratio).Select Variables All pts Pts<50 years of age HR P-value HR P-value Age at diagnosis (vs. ≥50yrs) 0.82 <0.0001 N/A N/A Female sex (vs.Male) 0.91 <0.0001 0.81 0.0045 Race (vs.White) Asian 0.84 <0.0001 0.57 0.0075 Year of Dx (vs.'88-'02) 2003-'07 0.96 0.0096 0.95 0.5562 2008-'11 0.94 0.0017 0.89 0.2796 Stage (vs.I) Stage II 1.22 0.0111 1.20 0.7255 Stage III 1.80 <0.0001 1.81 0.0282 Stage IV 2.93 <0.0001 3.81 <0.0001 Treatment (vs.None) Surgery 0.43 <0.0001 0.37 0.004 Chemotherapy 0.44 <0.0001 0.49 <0.0001 Radiation 0.66 <0.0001 0.71 <0.0001 Rural (vs.Urban) 0.97 0.3042 0.75 0.0419 Low SES {vs.High SES(4,5)} 1.05 0.0011 1.04 0.6306
Conclusion:
Age < 50 years was an independent predictor of improved CSS (HR 0.82, p<0.0001). In younger pts, female sex (HR 0.81, p=0.0045), Asian race (HR 0.57, p=0.0075), and rural residence (HR 0.75, p=0.042) were associated with better CSS, among other variables. Analyses for relevant interactions within subgroups will be presented.
