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K. Kaga



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    P1.06 - Poster Session 1 - Prognostic and Predictive Biomarkers (ID 161)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Biology
    • Presentations: 1
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      P1.06-010 - Expression of α1,6-fucosyltransferase is associated with prognosis and histology in non-small cell lung cancers (ID 1144)

      09:30 - 16:30  |  Author(s): K. Kaga

      • Abstract

      Background
      Lung cancer is one of the leading causes of cancer death throughout the world. A more sophisticated understanding of the pathogenesis and biology of NSCLCs could provide useful information for predicting clinical outcome and personalized treatment. α1,6-FT is the only one enzyme responsible for the core α1,6-fucosylation of N-glycans of glycoproteins, including EGF receptor, TGF-β1 receptor, and integrin α3β1.

      Methods
      α1,6-FT expression was studied by immunohistochemistry in a cohort of 129 surgically resected NSCLCs, classified categorically based on the proportion of positively stained cancer cells (high, > 20%; or low, < 20%), and analyzed statistically in relation to various characteristics, including histology, survival and prognosis.

      Results
      High and low expression of α1,6-FT was found in 67 and 62 of 129 NSCLCs, respectively. Multivariate logistic regression analysis revealed a significant association between high α1,6-FT expression and non-squamous cell carcinoma (mostly adenocarcinoma), as compared with squamous cell carcinomas (odds ratio, 3.51; p = 0.008). Patients with tumors having high α1,6-FT expression had significantly shorter survival time than patients with tumors having low expression in potentially curatively resected NSCLCs (p = 0.03) and adenocarcinomas (p = 0.009), as well as in pStage I NSCLCs (p = 0.03) by the log-rank test. Surprisingly, in pStage I adenocarcinomas, none of 15 patients with tumors having low expression died of lung cancer, although 12 of 23 patients with tumors having high α1,6-FT expression died of lung cancer. High α1,6-FT expression was a significant and independent unfavorable prognostic factor in potentially curatively resected NSCLCs (hazard ratio, 1.81; p = 0.047) and in pStage I NSCLCs (hazard ratio 2.55; p = 0.03) by Cox’s proportional hazards model analysis.

      Conclusion
      These results suggest that α1,6-FT may play a pivotal role for the biological characteristics of NSCLCs. α1,6-FT expression is associated with histology of NSCLCs, and may be a new prognostic marker for overall NSCLCs and adenocarcinomas.

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    P1.24 - Poster Session 1 - Clinical Care (ID 146)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Supportive Care
    • Presentations: 1
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      P1.24-031 - Confirmation of surgical margin of resected pulmonary adenocarcinoma with lepidic growth with thin slice CT of the resected specimen during surgery (ID 2288)

      09:30 - 16:30  |  Author(s): K. Kaga

      • Abstract

      Background
      Limited resections such as wedge resections for ground-glass opacity (GGO) adenocarcinomas have been proposed and widely performed. However there have been reports of cut-end recurrences after wedge resection of those lesions. One of the major obstacles to solve this problem is a lack of method to achieve thorough confirmation of surgical margin during surgery. Here we report a successful confirmation of cut-end using thin slice CT on resected lung specimen.

      Methods
      A patient with a ground-glass opacity in the right upper lobe underwent a wedge resection under thoracoscopy. The resected specimen was sent for thin slice CT scan, which revealed that there were enough surgical margins from the cut-end to the GGO lesion in any of 0.5mm thick slices. Figure 1 Figure 2

      Results
      Pathological examination confirmed that the cut-end was free from adenocarcinoma as being consistent with CT findings.

      Conclusion
      It is feasible and effective to confirm surgical margin of resected lung tumor with GGO during surgery using CT on the resected specimen.